Xilio Therapeutics

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Founded: 2018

Location: Waltham, MA

Employee range: 11 - 50

Clinical stage: Clin1

Therapy area: Solid Tumors

Drug types: ONC

Lead product: XTX101

Funding: $118M IPO Oct 2021; $95M C Feb 2021; $100.5M B Mar 2020; $30M A Sep 2018

Investors: F-Prime Capital Partners, Atlas Venture, Takeda

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Business:

Cancer Immunotherapies

Drug notes:

XTX202 Clin1 solid tumors; XTX301 Clin1 solid tumors

About:

Xilio Therapeutics is developing immunotherapies to improve cancer patient outcomes. Immunotherapy is the latest successful frontier in cancer treatment. Xilio is using their proprietary geographically precise solutions (GPS) platform to engineer novel molecules, including cytokines, to optimize therapeutics. The GPS platform designs molecules that only get activated in the tumor microenvironment, thus enhancing the molecules’ anti-tumor activity and localizing this potent activity. This has the benefit of reducing side effects seen in systemic therapies. Xilio is developing a range of molecules, with promising preclinical data for their lead candidates that show the potential of the system to create tumor-selective therapeutics. Xilio is also hoping to apply the GPS platform to inflammatory diseases.