Vor Biopharma is engineering hematopoietic stem cells (HSCs) to improve the efficacy of treating blood cancers. Current therapeutic strategies for blood cancers involve identifying unique targets on cancer cells. Vor is changing this paradigm by instead engineering healthy cells and making them invisible to targeted therapies. Vor’s approach reduces on-target toxicity of healthy cells by genetically modifying HSCs to remove surface targets expressed by cancer cells. Engineered HSCs are then transplanted back to patients and are then treatment resistant. Vor’s lead product, VOR33, showed promising preclinical data and is now entering clinical trials. The company is also conducting ongoing discovery efforts using their proprietary platform to identify additional surface targets.