Totus Medicines is using chemical biology to make the entire human genome druggable. Currently, 90% of targets to treat disease are considered “undruggable”, and Totus Medicine wants to change that. Using their high-throughput platform, Totus is discovering drugs with unprecedented volume and efficiency, thereby generating a catalog for  targets across the human genome. The platform exploits covalent chemistry and combines it with ultra-high throughput cell-based screening and AI/ML-powered drug design so that the library grows and learns over time. Totus is currently prioritizing untreatable diseases including specific cancers and heart diseases, but the ultimate aim is to have a searchable knowledge base of precision drugs.

<p>Totus Medicines is using chemical biology to make the entire human genome druggable. Currently, 90% of targets to treat disease are considered “undruggable”, and Totus Medicine wants to change that. Using their high-throughput platform, Totus is discovering drugs with unprecedented volume and efficiency, thereby generating a catalog for  targets across the human genome. The platform exploits covalent chemistry and combines it with ultra-high throughput cell-based screening and AI/ML-powered drug design so that the library grows and learns over time. Totus is currently prioritizing untreatable diseases including specific cancers and heart diseases, but the ultimate aim is to have a searchable knowledge base of precision drugs.</p>


Totus Medicines

Founded: 2019
Location: Emeryville, CA
Employee range: 11 - 50
Clinical stage: Clin1
Therapy area: Solid Tumors
Drug types: ONC
Lead product: TOS-358
Funding: $40M A Dec 2021

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