Business:
Cancer Therapeutics, Immuno-Oncology
Drug notes:
TNG462 Clin1/Clin2 oncology; TNG260 Clin1/Clin2 oncology; TNG348 Clin0 cancers
About:
Tango Therapeutics is using the principle of synthetic lethality to develop medicines for cancer patients. Synthetic lethality describes a situation where loss of two targets results in cell death, while loss of either one alone does not. Since some tumors already possess target loss, Tango is using their CRISPR-based functional genomics target discovery platform and analytic pipeline to identify novel synthetic lethal targets that can selectively kill tumor cells. Tango is applying this approach in two core areas: [1] tumor suppressor gene loss and [2] immune evasion. Once targets are identified, Tango screens for drugs that have therapeutic potential. Tango’s lead candidate, TNG908, is being evaluated in clinical trials for MTAP-deleted tumors.
Associate Director, Clinical Data and Technologies... Boston, MA|3 days ago
Clinical Trial Associate Boston, MA|4 days ago
Senior Manager, Clinical Compliance Boston, MA|5 days ago
Clinical Trial Manager Boston, MA|25 days ago