Tango Therapeutics

Tango Therapeutics is using the principle of synthetic lethality to develop medicines for cancer patients. Synthetic lethality describes a situation where loss of two targets results in cell death, while loss of either one alone does not. Since some tumors already possess target loss, Tango is using their CRISPR-based functional genomics target discovery platform and analytic pipeline to identify novel synthetic lethal targets that can selectively kill tumor cells. Tango is applying this approach in two core areas: [1] tumor suppressor gene loss and [2] immune evasion. Once targets are identified, Tango screens for drugs that have therapeutic potential. Tango’s lead candidate, TNG908, is being evaluated in clinical trials for MTAP-deleted tumors.

Jobs:

Director, Clinical Operations

Boston, MA|10 days ago

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Associate Scientist I/II, Immunology

Boston, MA|10 days ago

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Manager, Quality Assurance

Boston, MA|21 days ago

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Senior Director/VP, Corporate Communications

Boston, MA|22 days ago

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Director, Talent Acquisition

Boston, MA|31 days ago

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VP, Program Management

Boston, MA|32 days ago

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Associate Director/Director, Clinical Compliance

Boston, MA|50 days ago

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Clinical Drug Supply Manager

Boston, MA|63 days ago

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Clinical Trial Associate

Boston, MA|63 days ago

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Associate Director, Biomarker Development

Boston, MA|63 days ago

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Associate Director Clinical Informatics

Boston, MA|99 days ago

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Associate Director, Process Chemistry

Boston, MA|99 days ago

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Senior Scientist, Research Informatics

Cambridge, MA|100+ days ago

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Associate Director/Director, Regulatory Affairs

Cambridge, MA|100+ days ago

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Director / Senior Director, Clinical Development (2 openings...

Cambridge, MA|100+ days ago

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Director/Senior Director, Program Management

Boston, MA|100+ days ago

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Director, Intellectual Property

Cambridge, MA|100+ days ago

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