Stoke Therapeutics

Stoke Therapeutics

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  • Founded: 2014
  • Location: Bedford, MA
  • Employee range: 50 - 200
  • Clinical stage: Clin1/Clin2
  • Therapy area: Dravet syndrome (ODD)
  • Drug types: GEN, NEU, OPH, PED
  • Lead product: STK-001
  • Funding: $97.5M stock Nov 2020; $142M IPO Jun 2019; $90M B Oct 2018; $40M A Jan 2018


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Business:

Antisense Oligonucleotide Medicines

Drug notes:

STK-002 Clin1 autosomal dominant optic atrophy; undisclosed RD SYNGAP1 syndrome; undisclosed RD Rett syndrome; undisclosed RD CNS condition

About:

Stoke Therapeutics is using new insights in RNA biology to address the underlying cause of severe diseases. Many diseases arise when one copy of a gene functions normally and the other is mutated, called haploinsufficiency. Using their Targeted Augmentation of Nuclear Gene Output (TANGO) platform, Stoke is identifying ways to restore missing proteins by increasing protein output from healthy genes, thereby compensating for the non-functioning copy of the gene. The platform involves the design of antisense oligonucleotides (ASOs) that bind to pre-mRNA and help the target genes produce more protein. Stoke is currently applying their technology to patients with Dravet syndrome, a severe and progressive genetic epilepsy.

Stoke Therapeutics
Scientist I, Discovery Biology
Bedford, MA|5 days ago
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Stoke Therapeutics
Scientist I, Formulation
Bedford, MA|5 days ago
Stoke Therapeutics
Associate Director/Director, Clinical Science- Dat...
Bedford, MA|5 days ago
Stoke Therapeutics
Director, Statistical Programmer
Bedford, MA|5 days ago
Stoke Therapeutics
Principal Scientist, Oligonucleotide Chemistry
Bedford, MA|5 days ago
Stoke Therapeutics
Senior Manager, GCLP Compliance
Bedford, MA|15 days ago
Stoke Therapeutics
Senior Scientist, Bioinformatics
Bedford, MA|17 days ago
Stoke Therapeutics
Director, Regulatory Affairs, Global Regulatory St...
Bedford, MA|23 days ago
Stoke Therapeutics
Senior Director, Regulatory Labeling Development a...
Bedford, MA|23 days ago
Stoke Therapeutics
Executive Director, Field Medical Affairs
Cambridge, MA|45 days ago
Stoke Therapeutics
Director/Senior Director, Medical Affairs - Midwes...
Home, KS|52 days ago
Stoke Therapeutics
Executive Director/Vice President, Commercial Oper...
Bedford, MA|55 days ago
Stoke Therapeutics
Senior Director, Global Medical Information
Bedford, MA|58 days ago
Stoke Therapeutics
Director, Engineering & Facilities
Bedford, MA|62 days ago
Stoke Therapeutics
Research Associate, Biology
Bedford, MA|Posting date unknown
Stoke Therapeutics
Senior Analytical Scientist
Bedford, MA|Posting date unknown


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