Spring Discovery is discovering therapies for aging by targeting the underpinning biological processes. There is a growing wealth of data in model organisms showing that we can slow down the aging process. However, to bring these insights to understanding human aging, new technologies are required. Spring is using machine learning, high-dimensional data, lab automation and software to build the tools needed by scientists to understand the complex biology behind human aging. These tools include Spring’s experimental engine, Anvil, that can measure hundreds of cell behaviors across thousands of conditions in every experiment. Spring has applied this engine to discover therapies for age-related dysregulation of the immune response to viral infections.

<p>Spring Discovery is discovering therapies for aging by targeting the underpinning biological processes. There is a growing wealth of data in model organisms showing that we can slow down the aging process. However, to bring these insights to understanding human aging, new technologies are required. Spring is using machine learning, high-dimensional data, lab automation and software to build the tools needed by scientists to understand the complex biology behind human aging. These tools include Spring’s experimental engine, Anvil, that can measure hundreds of cell behaviors across thousands of conditions in every experiment. Spring has applied this engine to discover therapies for age-related dysregulation of the immune response to viral infections.</p>


Spring Discovery

Long Weekend Events and Things to do in Vancouver March 29-31, 2024 - Miss604

“Discovery Communications announced today plans to relocate its global headquarters from Silver Spring, Maryland, to New York City in 2019.” - PoPville

Spring Discovery Days - Northeast Ohio Parent

 Machine-learned feature correlations from high feature density biological … 

Cold spring discovered in S.China Sea, shedding light on flammable ice exploitation - People's Daily Online

Weekend Events in Vancouver Things to do March 22-24, 2024 - Miss604

Children’s National Is First Tenant to Sign at Inventa Towers in Silver Spring, Md. - Commercial Observer

❗❗❗ Beware of 'AI-washed' products in drug discovery and data analysis!❗❗❗

True innovation isn't about slapping an AI label on old tech. The Spring Engine represents genuine AI advancement, accelerating drug discovery like never before. We'll be digging deeper into this in the coming weeks, so stay tuned!

#AI #drugdiscovery #phenotypicprofiling

Houston’s Only Outdoor Roller Rink Opens At The Foot Of The City Skyline This Friday - Secret Houston

Signs of Spring Discovery Hike - West Newsmagazine

The Healing Power of Avène’s Thermal Spring Water-Based Skincare - Chatelaine


              A Combined AI and Cell Biology Approach Surfaces Targets and Mechanistically Distinct Inflammasome Inhibitors
            

March Events in Vancouver 2024 Monthly Calendar of Things to Do - Miss604

Paul Wall, Screen On The Green, And Roller Rink: Discovery Green’s Spring Program - Secret Houston

At Spring Science, we're pioneering the future of drug discovery through AI-powered image analysis. Our specialized models are revolutionizing how we identify and develop potential treatments, aligning with the vision of accelerated progress in biology and health outlined by industry leaders like Dario Amodei of Anthropic.

We're not just participants in this AI revolution - we're driving it forward. Our approach leverages smaller, specially trained AI models that excel at analyzing complex biological images. This targeted focus allows us to uncover insights and patterns that traditional methods might miss, potentially shaving years off the drug development timeline.

Imagine a world where breakthrough treatments for cancer, Alzheimer's, and other devastating diseases are discovered in months rather than decades. This isn't science fiction - it's the future we're building at Spring Science.

But we can't do it alone. We're calling on researchers, industry partners, and forward-thinking individuals to join us in this mission. Together, we can harness the power of AI to address global health challenges and usher in a new era of medical innovation.

How do you envision AI transforming healthcare? Share your thoughts and let's start a conversation about the incredible possibilities ahead. 

Read more in our new blog post: https://buff.ly/4f8OgWx 

#AIinHealthcare #DrugDiscovery #FutureofMedicine

MIT’s Orr-Weaver wraps up spring Discovery Lecture series April 26 - VUMC News

Spring break ideas that make learning fun - Houston ISD

‘Nothing left to really cut.’ Mecklenburg gives $10M to ballooning Discovery Place rebuild - Charlotte Observer

 Combination therapies with disulfiram 

Discovery: No Chompie for Shark Week This Year - DCist

Infinimmune Appoints Dr. Tim Sullivan as Chief Business Officer - Business Wire

Spring Discovery Raises $4.25M in Seed Funding - FinSMEs

Learn about BC’s longest river while playing a life-sized board game in New West - New West Record

8th Annual Tennessee STEAM Festival Kicks Off in Murfreesboro - Wgnsradio

End of an era in Silver Spring as Discovery sign is removed from HQ building - WJLA

This Spring on Discovery Velocity: Nationwide Free Preview Continues Through March, Return of AMERICARNA and BARRETT-JACKSON Auction, Plus New Seasons of DUAL SURVIVAL, NAKED SPEED - Bell Media

Exciting developments in live cell imaging are transforming how we observe cellular processes in real-time. A recent preprint introduces Live Cell Painting (LCP), a novel technique using Acridine Orange to visualize multiple cellular structures simultaneously without fixing cells.

At Spring Science, we're pushing similar boundaries with our live cell imaging platform. By combining brightfield and fluorescence microscopy (using live cell dyes ChromaLive by our friends at Saguaro Biosciences), researchers can now capture intricate cellular dynamics without disrupting normal function.

LCP demonstrates the power of non-invasive methods, revealing subtle changes in vesicle distribution and nuclear morphology in response to various compounds. Similarly, our experimental approaches allow for extended observation of living cells, providing rich phenotypic profiles that can uncover new insights into drug responses and disease mechanisms.

The preprint highlights LCP's ability to detect cellular changes at lower concentrations than traditional assays. This aligns with our mission to give scientists more sensitive tools for probing cellular behavior. Our platform's integration of advanced image analysis further empowers researchers to extract meaningful data from complex cellular behavior and morphology.

As we continue to refine live cell imaging techniques, the potential for accelerating drug discovery and deepening our understanding of cellular biology has never been greater. What cellular mysteries are you hoping to unravel with these advancing technologies? 

https://buff.ly/4e0LOzU 

#LiveCellImaging #CellBiology #DrugDiscovery 

Endpoint Health Appoints Ransi Somaratne, M.D. as Chief Medical Officer - Business Wire

 Methods, systems, and tools for longevity-related applications 

👻 Double, double, toil and trouble… 👻 

🧪 This Halloween, let’s unmask the ghostly repeat offenders lurking in drug screens. Just like the undead, some compounds keep reappearing as “hits” — but they’re not what they seem!  (we're talking about you, colchicine!)

💀 These “phantom hits” can haunt the drug discovery process, leading teams down dead-end paths and wasting resources. Time to exorcise these apparitions with smarter screening techniques!

#HalloweenScience #DrugDiscovery #AIinBiotech #NoMoreGhostHits

The Funded: 9 Bay Area startups raise nearly $340M at midweek - The Business Journals

Experience and discover: Volunteers drive spring events in Hamilton - Ag Proud

Spring Discovery Announces Company Rebrand to Spring Science →October 20, 2023News

Quality Holstein’s cow named grand champ five years running at Spring Discovery Show - FarmersForum.com

Weekend Events in Vancouver Things to do March 15-17, 2024 - Miss604

Discovery Education Announces Spring Lineup of Free Virtual Field Trips - THE Journal: Technological Horizons in Education

Spring Discovery Brings Machine Learning to Longevity Sector - The Wall Street Journal

Milestone Discovery Sale Features Military-Themed Items - Antiques and the Arts Online

Discovery Woods receives Crow Wing Energized School Partner Award - Brainerd Dispatch

Discover the residents of Chimp Haven this spring - Shreveport Times

Go on a Discovery Hunt in Polk County, Wisconsin! - Twin Cities Frugal Mom

Tastee Diner Silver Spring Sold For $3.1 Million - The MoCoShow


              Spring Science
            

Tastee Diner to Close its Silver Spring Location After 75+ Years - The MoCoShow

Ben Kamens' Spring Discovery: Antiaging Startup Raises Millions - Business Insider

 Use of aldh modulators or gasdermin d inhibitors for prevention and treatment … 

I observed emission from 2D semiconductors for 6 weeks — my ultra-thin display is now 30% brighter - Journée Mondiale

🚀 Unlock the Full Potential of Your Cell Painting Data with Spring Science! 🚀

Stop worrying about building complex, custom pipelines for your imaging data analysis. With Spring Science, everything you need is integrated and ready to go, making your research faster and more efficient.

🔍 Why Choose Spring?

Seamless Integration: Our platform is designed to be an extension of your lab, eliminating the need for deep coding expertise.

AI Embeddings for Superior Insights: Experience better accuracy and predictions with our state-of-the-art AI technology.

Proven Capability: We've analyzed hundreds of terabytes of Cell Painting datasets, showcasing our platform's capability to handle extensive data workloads.

Let's transform your research experience. Dive into the world of effortless data analysis with Spring Science!

#SpringScience #CellPainting #AI #DataAnalysis #ScientificInnovation

Winnipeg cops lay murder charges in spring discovery of human remains in North End - Global News Toronto

Ashland Daily Press Events - 1N (#14) Spring Discovery Walk at the Lincoln Community Forest - apg-wi.com

🎃 Not all cells go quietly… ☠️ Some die with a bang, others with a whimper, and Spring’s AI tools capture every haunting detail. This Halloween, we’re diving into the eerie world of cell death — from the chaos of necrosis to the fiery cascade of pyroptosis to the precision of apoptosis, each mechanism leaves a unique signature lurking in the shadows.

Spring’s AI brings these pathways to light, helping scientists reveal the mysteries of cell fate — no magic required! 🔮🕸️ Happy Halloween, and may your assays be as spooky as they are illuminating! 🧪👻

#HalloweenScience #CellDeath #TechBio #SpringScience #HauntedLabs

Quality Holsteins dominate Spring Discovery Show five years running - FarmersForum.com

Costa Concordia Disaster to Become Discovery Channel Special (Exclusive) - Hollywood Reporter

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