Spatial Genomics

Molecular barcoding, imaging, FISH

Spatial Genomics is analyzing biomolecules and mapping their location within single cells. Many techniques to understand the biochemical workings of a cell require the cell to be broken up. This results in the loss of spatial information that can inform fundamental biology, precision medicine, drug development and diagnostics. Spatial Genomics reveals biology by simultaneously assaying single-cell gene expression, protein expression, and genomic and epigenomic states within intact cells and tissues. The technology involves sequential fluorescence in situ hybridization (seqFISH) that merges imaging and combinatorial molecular barcoding. This allows researchers to get information not just on cell state, but on cell interactions and neighborhoods.