Rational Vaccines is researching infectious diseases to improve the treatment, prevention and diagnosis of herpes worldwide. Smallpox virus was successfully eradicated through the use of a live-attenuated vaccine. Now, Rational Vaccines is applying the science of attenuating live viruses to develop an entirely new class of therapeutic and prophylactic herpes treatments. Rational Vaccines proprietary vaccine candidates carry attenuating mutations in a key viral gene that encodes the protein ICPO which controls the balance between herpes latency and replication - their lead candidate, RVx-201, has shown positive antibody responses in preclinical studies.

Rational Vaccines

Founded: 2015
Location: Woburn, MA
Employee range: 1 - 10
Clinical stage: Clin0
Therapy area: HSV-2 treatment
Drug types: INF, VAC
Lead product: RVx-201

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