Short description:
ALS cure - Small Molecules, ASO
Drug notes:
QRL-201/QRL-203 Clin0 FTD, Clin0 PLS; QRL-101 Clin1 ALS, Clin0 FTD; QRL-204 Clin0 ALS/FTD, Clin0 FTD
Long description:
QurAlis is using advances in precision medicine to develop therapeutics for neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that reduces muscle function and control. By examining the disease-causing genetic alterations linked with ALS, QurAlis is targeting these disease mechanisms using human neuronal stem cell models from ALS patients - this includes the gene that encodes the protein TDP-43. QuAlis has a second platform, FlexASO, a proprietary anti-sense oligonucleotide splice modulator platform to selectively modulate RNA levels to change the expression of genes connected to disease. With these approaches, QurAlis has already established a pipeline of programs in clinical stages.
Jobs:
Senior Scientist Cambridge, MA|4 days ago
Director of Drug Substance Manufacturing Cambridge, MA|8 days ago
Medical Director Cambridge, MA|8 days ago
Director Clinical Supply Chain Cambridge, MA|10 days ago
Biofluid Repository Consultant Cambridge, MA|37 days ago
Senior Director Quality Assurance Cambridge, MA|50 days ago
Biomarker Scientist Cambridge, MA|50 days ago
Project Team Lead Cambridge, MA|59 days ago