Pliant Therapeutics

Pliant Therapeutics

  • Founded: 2016
  • Location: South SF, CA
  • Employee range: 50 - 200
  • Clinical stage: Clin2b
  • Therapy area: Idiopathic pulmonary fibrosis
  • Drug types: HEP, LNG, ONC, MUS
  • Lead product: PLN-74809 (bexotegrast)
  • Product link: https://pliantrx.com/pipeline/
  • Funding: $287.5M stock Jan 2023; $230M stock Jul 2022; $165M IPO Jun 2020; $100M C Feb 2020; $62M Jul 2018; $45M A Feb 2016
  • Investors: Novartis


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Short description:

Treatments for fibrotic diseases

Drug notes:

Also Clin2 primary sclerosing cholangitis; PLN-1474 Clin1 NASH fibrosis; PLN101325 Clin0 muscular dystrophies; undisclosed Clin0 solid tumors

Long description:

Pliant Therapeutics is understanding the molecular drivers of fibrotic diseases to identify safer and more effective therapies for patients. Fibrosis occurs when cells repair tissue damage through the formation of fibrotic scars, which when overactivated can cause irreparable damage and disease. TGF-β is a key driver of fibrosis that investigational therapies are targeting; however, it risks toxicity to a patient’s healthy tissues. Instead, Pliant is using their expertise in integrin biology, proteins downstream of TGF-β in the fibrosis cascade, to identify more selective therapies. Pliant is building a pipeline of integrin inhibitors using their screening platform, live fibrotic human tissue assays and biomarker assays. Their lead candidate, PLN-74809, is in clinical trials.

Jobs:

Pliant Therapeutics
Buyer
South San Francisco, CA|4 days ago
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Pliant Therapeutics
Clinical Trial Manager
South San Francisco, CA|8 days ago
Pliant Therapeutics
Senior Director, Quality Assurance
South San Francisco, CA|16 days ago
Pliant Therapeutics
CMC Intern
South San Francisco, CA|21 days ago
Pliant Therapeutics
Accounting Intern
South San Francisco, CA|21 days ago
Pliant Therapeutics
Portfolio & Program Management
South San Francisco, CA|21 days ago
Pliant Therapeutics
Scientist I, Non-Clinical Safety
South San Francisco, CA|31 days ago
Pliant Therapeutics
Associate Director, Enterprise Applications
South San Francisco, CA|42 days ago
Pliant Therapeutics
Patent Agent
South San Francisco, CA|51 days ago
Pliant Therapeutics
Associate Director, Program Management
South San Francisco, CA|72 days ago
Pliant Therapeutics
Senior Director, Regulatory Affairs - Strategy
South San Francisco, CA|91 days ago
Pliant Therapeutics
Senior Director, Regulatory Affairs - Strategy/Adv...
South San Francisco, CA|91 days ago
Pliant Therapeutics
Director, Clinical Operations
South San Francisco, CA|100+ days ago
Pliant Therapeutics
Vice President, Quality (GXP)
South San Francisco, CA|100+ days ago
Pliant Therapeutics
Director, Clinical Quality Assurance
South San Francisco, CA|100+ days ago
Pliant Therapeutics
Translational Sciences Biomarker Specialist
South San Francisco, CA|100+ days ago


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