Pliant Therapeutics

Pliant Therapeutics is understanding the molecular drivers of fibrotic diseases to identify safer and more effective therapies for patients. Fibrosis occurs when cells repair tissue damage through the formation of fibrotic scars, which when overactivated can cause irreparable damage and disease. TGF-β is a key driver of fibrosis that investigational therapies are targeting; however, it risks toxicity to a patient’s healthy tissues. Instead, Pliant is using their expertise in integrin biology, proteins downstream of TGF-β in the fibrosis cascade, to identify more selective therapies. Pliant is building a pipeline of integrin inhibitors using their screening platform, live fibrotic human tissue assays and biomarker assays. Their lead candidate, PLN-74809, is in clinical trials.

Jobs:

Manager/Senior Manager, Analytical Development and Quality C...

South San Francisco, CA|11 days ago

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Manager/Senior Manager, Quality Assurance

South San Francisco, CA|12 days ago

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Program Management Intern

South San Francisco, CA|13 days ago

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Clinical Operations Intern

South San Francisco, CA|32 days ago

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Intellectual Property Intern

South San Francisco, CA|32 days ago

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Accounting Intern

South San Francisco, CA|32 days ago

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Analytical Chemistry Intern

South San Francisco, CA|32 days ago

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Medicinal Chemistry Intern

South San Francisco, CA|32 days ago

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Senior Manager/Associate Director, Quality Assurance

South San Francisco, CA|33 days ago

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Manager/Senior Manager, Clinical Supply Chain Management

South San Francisco, CA|33 days ago

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Director, Clinical Operations

South San Francisco, CA|43 days ago

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IT Support Engineer

South San Francisco, CA|43 days ago

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Senior Manager, Regulatory Affairs CMC

South San Francisco, CA|43 days ago

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Contracts Manager (Non-Clinical)

South San Francisco, CA|50 days ago

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Clinical Trial Manager

South San Francisco, CA|60 days ago

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Manager/Sr. Manager, Scientific Communications

South San Francisco, CA|61 days ago

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Associate Director/Director, Nonclinical Safety Project Lead...

South San Francisco, CA|62 days ago

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Sr. Manager, Portfolio and Program Management (Clinical Dev....

South San Francisco, CA|74 days ago

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Principal Biostatistician, Biostatistics

South San Francisco, CA|99 days ago

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Clinical Site Liaison

South San Francisco, CA|100+ days ago

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Clinical Site Liaison Manager

South San Francisco, CA|100+ days ago

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Associate Director/Director, DMPK

South San Francisco, CA|100+ days ago

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Senior Manager, DMPK

South San Francisco, CA|100+ days ago

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Associate Director, SEC Reporting & Technical Accounting

South San Francisco, CA|100+ days ago

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Associate Director/Director, Clinical Development

South San Francisco, CA|100+ days ago

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Senior Director, Early-Stage Development and New Indications...

South San Francisco, CA|100+ days ago

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