PIC Therapeutics

PIC Therapeutics is developing small molecule therapeutics that target the pre-initiation complex (PIC) to treat cancer patients. The PIC refers to the complex of proteins that gather to initiate translation of mRNA to proteins. Essentially, since cancer cells typically have dysregulated protein synthesis, by targeting the PIC, PIC is hoping to modulate RNA translation. To identify small molecule therapeutics, PIC is using structural studies of translation initiation factors. Using their precision-based therapeutic approach, PIC hopes to reduce oncogenic translation while preserving translation of non-oncogenic proteins in an array of cancer types regardless of molecular heterogeneity.

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