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Nurix Therapeutics

Company info:

101-250

2012

San Francisco, CA

100-500M

nurixtx.com

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About company:

Nurix Therapeutics is discovering and developing therapies that modulate protein levels to treat cancer. Proteins are the workhorse of a cell and can become overexpressed, underexpressed or over-activated in diseases like cancer. Nurix is addressing these diseases through ‘Targeted Protein Modulation’ that enables tuning of specific protein levels. This can be used to destroy disease-causing proteins or to inhibit protein degraders and raise the level of beneficial proteins. Discovery involves use of Nurix’s DELigase platform to identify small molecules that bind their collection of E3 ligases. Nurix has identified a CBL-B ligase inhibitor that they are using to create superior adoptive cell therapies which are entering clinical trials.