Nurix Therapeutics

Nurix Therapeutics

  • Founded: 2009
  • Location: San Francisco, CA
  • Employee range: 200 - 500
  • Clinical stage: Clin1b
  • Therapy area: B-cell malignancies
  • Drug types: ONC, RHU, IMM
  • Lead product: NX-2127
  • Product link: https://www.nurixtx.com/pipeline/
  • Funding: $40M stock Jul 2022; $55M stock Jul 2022; $160M stock Mar 2021; $209M IPO Jul 2020; $120M Mar 2020
  • Investors: Foresite Capital, Bain Capital Life Sciences, Boxer Capital (Tavistock Group), EcoR1 Capital, Redmile Group, Wellington Management Company, The Column Group, Third Rock Ventures


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Short description:

Small Molecules, Protein Degradation

Drug notes:

NX-5948 Clin1a B-cell malignancies; NX-1607 Clin1a immuno-oncology; NX-0479 Clin0 rheumatoid arthritis, inflammatory diseases; 3 undisclosed programs RD undisclosed

Long description:

Nurix Therapeutics is discovering and developing therapies that modulate protein levels to treat cancer. Proteins are the workhorse of a cell and can become overexpressed, underexpressed or over-activated in diseases like cancer. Nurix is addressing these diseases through ‘Targeted Protein Modulation’ that enables tuning of specific protein levels. This can be used to destroy disease-causing proteins or to inhibit protein degraders and raise the level of beneficial proteins. Discovery involves use of Nurix’s DELigase platform to identify small molecules that bind their collection of E3 ligases. Nurix has identified a CBL-B ligase inhibitor that they are using to create superior adoptive cell therapies which are entering clinical trials.

Jobs:

Nurix Therapeutics
Sr Manager/AD Regulatory Affairs (small molecules)...
San Francisco|2 days ago
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Nurix Therapeutics
Scientist I / Senior Scientist – Immunology
San Francisco|10 days ago
Nurix Therapeutics
Payroll and Equity Manager
San Francisco|10 days ago
Nurix Therapeutics
Senior Director of GCP Clinical Quality Assurance ...
San Francisco|10 days ago
Nurix Therapeutics
Senior Research Associate/Scientist I – In vitro A...
San Francisco|11 days ago
Nurix Therapeutics
Medical Director - Senior Medical Director, Clinic...
San Francisco|11 days ago
Nurix Therapeutics
Associate Director/ Director, Chemical Development...
San Francisco|11 days ago
Nurix Therapeutics
Associate Director/ Sr Scientist, Chemical Develop...
San Francisco|11 days ago
Nurix Therapeutics
Research Associate/Sr. Research Associate – Discov...
San Francisco|11 days ago
Nurix Therapeutics
SRA – Cell Biology and Immunology - Discovery Biol...
San Francisco|11 days ago
Nurix Therapeutics
Senior Director/Executive Director, Analytical Dev...
San Francisco|11 days ago
Nurix Therapeutics
Senior Specialist / Associate Manager - Quality As...
San Francisco|11 days ago


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