Notch Therapeutics

Gene-modified T cell therapy

Also Clin0 Solid & hematologic malignancies; T Regulatory Cells Clin0 autoimmune diseases; undisclosed programs RD undisclosed

Notch Therapeutics is manufacturing therapeutic T cells from pluripotent stem cells using their understanding of Notch signaling. Notch genes encode a family of receptors that drive cell fate decisions by binding ligands and transmitting signals between adjacent cells. By uncovering that Notch signaling is important for T cell development, Notch Therapeutics is taking an engineering approach to solve major bottlenecks in iPSC-derived T cell manufacturing. In this way, exploiting the Notch signaling pathway enables T cells to be matured without the need for a thymus. The advantage of starting with iPSCs which can be cultured at massive scale means that Notch has a potentially limitless source of starting materials for the production of therapeutically relevant cells.

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