Drug discovery using cryogenic electron microscopy
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Gandeeva Therapeutics is using the power of cryo-EM and machine learning to advance drug discovery. Cryo-EM is a microscopy method that enables visualization of protein structures. Protein structures and their interactions are altered in almost all diseases. Using advances in resolution of cryo-EM in their platform, Gandeeva is imaging protein interfaces and using machine learning to develop precision medicines to treat challenging diseases. The Cryo-EM engine, HYPERFOCUS, enables mapping of druggable sites onto atomic resolution protein images. Gandeeva’s approach will tackle many targets from allosteric proteins, protein-protein complexes, nucleic acid protein complexes to membrane proteins using therapies ranging from small molecules to engineered antibodies.