EnPlusOne Biosciences

EnPlusOne Biosciences

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  • Founded: 2022
  • Location: Watertown, MA
  • Employee range: 1 - 10
  • Funding: $12M Seed Sep 2022
  • Investors: Northpond Ventures, Breakout Ventures, Coatue


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Enzymatic RNA Synthesis Platform

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EnPlusOne Biosciences is harnessing the power and flexibility of enzymes to develop RNA therapeutics. There is currently a lot of interest in creating RNA therapeutics but a lack of companies that can generate the diverse forms of RNA efficiently. Using their proprietary ezRNATM platform, EnPlusOne is building RNA enzymatically to promise long-term manufacturing solutions to sustainably deliver RNA therapeutics at scale. These abilities range from de novo RNA synthesis to single RNA extensions off of therapeutic payloads, as well as incorporating a diverse array of nucleotide modifications, all using aqueous-based reaction conditions.

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