Short description:
Chimeric Auto Antibody Receptors
Drug notes:
MuSK-CAART Clin1 myasthenia gravis; PLA2R-CAART Clin0 membranous nephropathy; CABA-201 3 efforts Clin0 SLE, undisclosed; DSG3/1-CAART RD mucocutaneous pemphigus vulgaris
Long description:
Cabaletta Bio is developing T cell therapies for patients with B cell-mediated autoimmune diseases. Engineered T cell therapy takes advantage of T cell’s natural cell-killing capabilities and redirects their specificity to disease-causing cells by inserting a gene encoding a specific receptor. Known as chimeric antigen receptor (CAR) T cells, this approach has shown much success in cancer treatment. Cabaletta is encompassing CAR T cells for Autoimmunity (CARTA) which they hope to apply to many B cell-mediated autoimmune diseases. Cabaletta’s lead candidate in preclinical stages, CABA-201, is a fully human CD19 CARTA approach which has the potential to eliminate disease-causing B cells and allow for healthy B cell repopulation.
Jobs:
Senior Scientist, Process Development Philadelphia, Pennsylvania|Not provided
Lab Information Management (LIMS) Administrator Philadelphia, Pennsylvania|Not provided
Director, Quality Assurance Operations Philadelphia, Pennsylvania|Not provided
GLP Quality Control Specialist Philadelphia, Pennsylvania|Not provided
QA & Compliance LMS Training Specialist Philadelphia, Pennsylvania|Not provided
Senior Director, Process Development Philadelphia, Pennsylvania|Not provided
Associate Director/Director, Clinical Data Managem... All, All|Not provided
Research Associate/Sr. Research Associate, Molecul... Philadelphia, Pennsylvania|Not provided
Associate Director / Director Statistical Programm... All, All|Not provided
Senior Scientist/Scientist, Molecular Genomics (Ce... Philadelphia, Pennsylvania|Not provided
Project Manager/Senior Project Manager, CMC Philadelphia, Pennsylvania|Not provided
Manager/Senior Manager, GMP Quality Control Philadelphia, Pennsylvania|Not provided
Vice President/Sr. Director., Associate General Co... Philadelphia, PA|Not provided
Senior Scientist, Lentiviral Vectors (Cell Therapy... Philadelphia, Pennsylvania|Not provided
IT Laboratory Systems Administrator/Analyst Philadelphia, Pennsylvania|Not provided
Associate Director/Director, Clinical Scientist (R... All, All|Not provided
Finance and Human Resources Coordinator Philadelphia, Pennsylvania|Not provided
Associate Scientist/Scientist, Analytical Developm... Philadelphia, Pennsylvania|Not provided
Supply Chain Logistics Coordinator Philadelphia, Pennsylvania|Not provided
Senior IT Systems Administrator Philadelphia, Pennsylvania|Not provided
Scientist/Sr Scientist, Translational Research Philadelphia, Pennsylvania|Not provided
TMF Inspection Readiness Associate Philadelphia, PA|Not provided
Sr. Process Engineer, MS&T Philadelphia, PA|Not provided
Associate Scientist/Scientist, Analytical Developm... Philadelphia, Pennsylvania|Not provided
Senior Manager, Technical Writer, Regulatory Affai... All, All|Not provided
Manager/Sr. Manager, Technical Writing – CMC Regul... Philadelphia, Pennsylvania|Not provided
Medical Director/Senior Medical Director, Medical ... All, All|Not provided
Associate Principal Scientist/Senior Scientist, An... Philadelphia, Pennsylvania|Not provided
Associate Scientist/Scientist, Analytical Developm... Philadelphia, Pennsylvania|Not provided
Associate Laboratory Manager Philadelphia, Pennsylvania|Not provided