Short description:
Chimeric Auto Antibody Receptors
Drug notes:
MuSK-CAART Clin1 myasthenia gravis; PLA2R-CAART Clin0 membranous nephropathy; CABA-201 3 efforts Clin0 SLE, undisclosed; DSG3/1-CAART RD mucocutaneous pemphigus vulgaris
Long description:
Cabaletta Bio is developing T cell therapies for patients with B cell-mediated autoimmune diseases. Engineered T cell therapy takes advantage of T cell’s natural cell-killing capabilities and redirects their specificity to disease-causing cells by inserting a gene encoding a specific receptor. Known as chimeric antigen receptor (CAR) T cells, this approach has shown much success in cancer treatment. Cabaletta is encompassing CAR T cells for Autoimmunity (CARTA) which they hope to apply to many B cell-mediated autoimmune diseases. Cabaletta’s lead candidate in preclinical stages, CABA-201, is a fully human CD19 CARTA approach which has the potential to eliminate disease-causing B cells and allow for healthy B cell repopulation.
Jobs:
Lab Information Management (LIMS) Administrator Philadelphia, Pennsylvania|Not provided
Senior Scientist, Lentiviral Vectors (Cell Therapy... Philadelphia, Pennsylvania|Not provided
IT Laboratory Systems Administrator/Analyst Philadelphia, Pennsylvania|Not provided
Associate Director/Director, Clinical Scientist (R... All, All|Not provided
Senior IT Systems Administrator Philadelphia, Pennsylvania|Not provided
Associate Scientist/Scientist, Analytical Developm... Philadelphia, Pennsylvania|Not provided
Associate Laboratory Manager Philadelphia, Pennsylvania|Not provided
Director, Clinical Trial Liaison (Remote) All, All|Not provided
Biostatistics Intern Philadelphia, Pennsylvania|Not provided
Bioinformatics Intern Philadelphia, Pennsylvania|Not provided
Senior Research Associate/ Associate Scientist, Tr... Philadelphia, Pennsylvania|Not provided
Associate Scientist, Process Development Philadelphia, Pennsylvania|Not provided
Associate Director/Director, Protein & Molecular B... Philadelphia, Pennsylvania|Not provided
Director/Senior Director, Regulatory Affairs (Remo... All, All|Not provided
Associate Project Manager / Project Manager - Clin... All, All|Not provided
Associate Clinical Sample Manager (Remote) All, All|Not provided