Business:
Chimeric Auto Antibody Receptors
Drug notes:
MuSK-CAART Clin1 myasthenia gravis; PLA2R-CAART Clin0 membranous nephropathy; CABA-201 3 efforts Clin0 SLE, undisclosed; DSG3/1-CAART RD mucocutaneous pemphigus vulgaris
About:
Cabaletta Bio is developing T cell therapies for patients with B cell-mediated autoimmune diseases. Engineered T cell therapy takes advantage of T cell’s natural cell-killing capabilities and redirects their specificity to disease-causing cells by inserting a gene encoding a specific receptor. Known as chimeric antigen receptor (CAR) T cells, this approach has shown much success in cancer treatment. Cabaletta is encompassing CAR T cells for Autoimmunity (CARTA) which they hope to apply to many B cell-mediated autoimmune diseases. Cabaletta’s lead candidate in preclinical stages, CABA-201, is a fully human CD19 CARTA approach which has the potential to eliminate disease-causing B cells and allow for healthy B cell repopulation.
Senior Director, CMC Regulatory Affairs (Hybrid) Philadelphia, Pennsylvania|Not provided
Associate Operations Manager, Translational Medici... Philadelphia, Pennsylvania|Not provided
Senior Research Associate/ Associate Scientist, Tr... Philadelphia, Pennsylvania|Not provided
Process Engineer, Person-In-Plant Houston, TX|Not provided
Scientist, Process Development Philadelphia, Pennsylvania|Not provided
Process Engineering Associate, Person-In-Plant Philadelphia, PA|Not provided
Associate Director / Director, Clinical Scientist Philadelphia, PA|Not provided
Sr. Manager/Associate Director, Supply Chain Opera... Berlin, Brandenburg|Not provided
Medical Director/Senior Director, Clinical Develop... Philadelphia, Pennsylvania|Not provided
Senior Research Associate, Computational Biology Philadelphia, Pennsylvania|Not provided