Bonum Tx

Bonum Therapeutics is creating a new class of regulated protein therapeutics to attain targeted biological activity against cancer. Cytokines are proteins that have a broad immuno-stimulatory activity, including cancer cells, but are limited by significant toxicity. To overcome this limitation, Bonum is designing two component molecules that include the cytokine and a sensor component. The sensor is an antibody binding domain directed against a tissue or cell target that induces activation of the therapeutic on binding its target. Currently, Bonum is focused on developing regulated cytokines that can be used to treat cancer. However, there is also potential to target autoimmune diseases and metabolic disorders.

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