Drug notes:
BDTX-4933 Clin0 solid tumors, CNS tumors; 2 undisclosed programs RD solid tumors
About:
Black Diamond Therapeutics is developing small molecule therapies to meet the unmet need for precision oncology. Cancer is a genetic disease of which many are caused by mutations in oncogenes. Using their proprietary Mutation-Allostery-Pharmacology (MAP) drug discovery engine, Black Diamond is analyzing population-level genetic sequencing data to identify oncogenic mutations that promote cancer and aggregate the mutations into families. After creating mutation families, Black Diamond can develop a single spectrum-selective therapy that targets a specific family of mutations. Using their MAP discovery engine, Black Diamond is developing a pipeline of orally available, potent and selective drug candidates including their lead candidate, BDTX-1535, a brain-penetrant inhibitor of EGFR mutations.