Annexon Biosciences is developing novel therapeutics for neurodegenerative and autoimmune disorders. An important process involved in immune signaling is activation of the complement cascade. Annexon is focused on stopping the initiation of the classical complement pathway, which activates a powerful inflammatory response seen in autoimmune and neurodegenerative diseases. A key component of this cascade, C1q, accumulates and binds to tissues in complement-mediated diseases. To stop initiation of the cascade, Annexon is identifying therapies that target C1q, which is an early complement pathway protein, thereby preventing the cascade from activating damaging components of the immune system. Currently, Annexon is conducting ongoing clinical trials in multiple serious diseases of the body, brain and eye.