AnHeart Therapeutics

AnHeart Therapeutics

  • Founded: 2018
  • Location: Hangzhou, China
  • Employee range: 50 - 200
  • Clinical stage: Clin2
  • Therapy area: NSCLC, solid tumors
  • Drug types: ONC
  • Lead product: Taletrectinib/AB-106
  • Product link:
  • Funding: $61M B Dec 2021; $14.6M A May 2019

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Short description:

Orally available small molecule

Drug notes:

Safusidenib Clin2 glioma, Clin1 cholangiocarcinoma, Clin1 solid tumors; AB-329 2 trials Clin1 NSCLC, Clin1 solid tumors; 5+ undisclosed programs Clin0 undisclosed

Long description:

AnHeart Therapeutics is developing novel precision oncology therapeutics for areas of unmet clinical need. AnHeart’s lead candidate, taletrectinib, is currently in Phase 2 trials in a subset of patients with non-small cell lung cancer (NSCLC). Taletrectinib inhibits the protein ROS1, which is mutated in ~2% of NSCLC patients and several other cancers. While first generation ROS1 inhibitors exist, there are patients who are resistant to treatment due to treatment-resistant mutations. AnHeart developed Taletrectinib to show potency against resistance tumors and has so far shown a strong safety profile and can pass the blood brain barrier with potential to address brain metastasis. AnHeart is also advancing many other precision oncology clinical programs.


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