AN2 Therapeutics is developing treatments for rare, chronic and serious infections with high unmet medical need. Traditional drug discovery typically starts with small molecules based on natural products or peptides which tend to not contain boron. However, boron-based compounds are typically selective for their biological target. AN2 is tuning the reactive center of boron-based compounds to identify drugs that can target sites within the body with good pharmacokinetics. AN2’s lead candidate, Epetraborole, is a boron-containing, orally-available, small molecule that inhibits an essential step in protein synthesis that they have developed for the treatment of non-tuberculous mycobacterial lung disease.
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