Ambagon Therapeutics is enhancing the activity of tumor suppressors by creating cancer molecule therapeutics. 14-3-3 proteins are adaptor proteins that play a key role in a large number of disease-related pathways, but are intrinsically disordered, making it hard to design small molecule binders. However, these disordered regions become ordered when 14-3-3 binds other “client” protein interactors. Different clients create structurally unique pockets on 14-3-3 enabling Ambagon to develop small molecules that can stabilize specific 14-3–3:client interactions. Ambagon has built an extensive database of 14-3-3:client protein structures to quickly identify the most promising candidates for screening. Amabagon now has five programs in early discovery and expects one to reach development by 2023.

<p>Ambagon Therapeutics is enhancing the activity of tumor suppressors by creating cancer molecule therapeutics. 14-3-3 proteins are adaptor proteins that play a key role in a large number of disease-related pathways, but are intrinsically disordered, making it hard to design small molecule binders. However, these disordered regions become ordered when 14-3-3 binds other “client” protein interactors. Different clients create structurally unique pockets on 14-3-3 enabling Ambagon to develop small molecules that can stabilize specific 14-3–3:client interactions. Ambagon has built an extensive database of 14-3-3:client protein structures to quickly identify the most promising candidates for screening. Amabagon now has five programs in early discovery and expects one to reach development by 2023.</p>


Ambagon Therapeutics

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