• Founded: 2018
  • Location: Cambridge, MA
  • Employee range: 11 - 50
  • Clinical stage: RD
  • Therapy area: Genetic mutation driven diseases
  • Drug types: GEN
  • Lead product: Undisclosed
  • Product link:
  • Funding: $109M B Aug 2023; $50M Nov 2021
  • Investors: Flagship Pioneering

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Short description:

tRNA therapies

Drug notes:

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Long description:

Alltrna is building a platform to design tRNAs that treat genetic diseases. The platform applies machine learning to design a library of tRNAs, including those with chemical modifications that impact the tRNAs' structure. The tRNAs are synthesized and evaluated for therapeutic potential via automated, high-throughput in vitro assays and studies in animal models. The data is used in Alltrna's machine learning tools to understand how sequence, structure, and modifications can be optimized. As an initial approach, Alltrna is treating genetic diseases where a nonsense mutation creates a stop codon, which results in a truncated protein. Alltrna has designed tRNAs that can read stop codons within specific mutated genes and deliver the correct amino acid to create the full-length protein.


Executive Assistant and Office Administrator
Cambridge, MA|11 days ago
Data Engineer, Lab Informatics
Cambridge, MA|14 days ago
Research Associate, Molecular & Cellular Biology
Cambridge, MA|14 days ago

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