Acrivon Therapeutics

Checkpoint Inhibitor

Also Clin2 (fast track) endometrial cancer, Clin2 bladder cancer, 3 combo trials Clin2 multiple cancers; ACR-2316 RD/Clin0 oncology; 2 undisclosed programs RD oncology, undisclosed

Acrivon Therapeutics is using a proteomics-based approach to develop precision oncology therapeutics. While the underlying basis of cancer is genomic alterations, it is the dysregulated proteome that drives the disease. Proteomic biomarkers therefore offer a more accurate matching of patients with drugs than genomic biomarkers. Acrivon is using their proprietary Predictive Precision Proteomics platform to develop patient selection tumor biopsy tests, called OncoSignature® tests, to identify which patients will benefit from a specific drug, matching drug mechanisms to the biologic drivers of cancer. Acrivon’s clinical pipeline is currently focused on advanced assets targeting the DNA damage response where traditional patient selection is challenging, with Phase 2 trials initiated.