A-Alpha Bio

A-Alpha Bio

  • Founded: 2017
  • Location: Seattle, WA
  • Employee range: 11 - 50
  • Funding: $22.4M A2 Jul 2023; $20M A Sep 2021; $2.8M seed Sep 2019; $225 NSF grant Jul 2018



job board

Short description:

Yeast-based Drug Assay

Drug notes:

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Long description:

A-Alpha Bio is accelerating drug discovery by providing cell-based tools of protein interactions. Protein interactions govern all cellular processes and are therefore linked with disease. However, while predictive tools are now available for an individual protein structure, understanding protein interactions requires time-consuming experimentation. A-Alpha is circumventing this by generating high-quality protein-protein interaction data by measuring millions of protein-protein interactions at a time using AlphaSeq. AlphaSeq combines yeast two-hybrid technology with DNA barcodes to read out high-affinity interactions. This approach can be used to discover effective antibodies and degradable neo-substrates, engineer protein interfaces, and fuel predictive machine learning models.


A-Alpha Bio
Process Engineer I
Seattle, WA|3 days ago
A-Alpha Bio
Scientist I, Antibody Discovery
Seattle, WA|18 days ago
A-Alpha Bio
Senior Scientist, Machine Learning
Seattle, WA|66 days ago
A-Alpha Bio
Director, Applied Data Science
Seattle, WA|73 days ago
A-Alpha Bio
Principal Scientist, Immunobiology
Seattle, WA|88 days ago

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