Computational Synthetic Biology
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20n Bio is using computational biology to design novel molecules such as protein therapeutics. At the core of 20n Bio’s philosophy is their open source platform for synthetic biology. Synthetic biology involves using the blueprint of DNA to make molecules biologically and more sustainably. 20n has used their approach to invent organisms that make acetaminophen/paracetamol (APAP) by fermenting sugar. 20n achieved this by engineering an E.coli and a yeast with a gene from a mushroom and over-expression of two native genes. The entire supply of APAP can be generated from petroleum. By using deep learning and biochemistry, 20n offers their Bioreachable Service platform to help teams identify new molecules, or discover more efficient ways to reach a product.