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AI Proteins

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ALX Oncology

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ARTBIO

AS2 Bio Inc

AUM BioTech

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Ab Studio

Abalone Bio

Abata Therapeutics

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Absci

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Accent Therapeutics

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Achieve Life Sciences

Acomhal Research

Acrivon Therapeutics

Actym Therapeutics, Inc.

Acutis Diagnostics

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Adcentrx Therapeutics

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Aditum Bio

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Adverum Biotechnologies

Aeglea BioTherapeutics

Aera Therapeutics

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Affini-T Therapeutics

Affinia Therapeutics

AgBiome

Agastiya Biotech

Agena Bioscience

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Ainnocence

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Aixa Bio

Akero Therapeutics

Akita Biosciences

Akouos

Akttyva Therapeutics

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Aldebaran Therapeutics

Alector

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AlivaMab Discovery Services

Alkahest

Alladapt Immunotherapeutics

Allakos

Allarta Life Science

Allay Therapeutics

AlloVir

Alloy Therapeutics

Alltrna

AlpaLifeBio

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Alpine Immune Sciences

AltPep

Alterome Therapeutics

Altis Biosystems

Alto Neuroscience

Alumis

Alveo Technologies

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Alzheon

AmbAgon Therapeutics

Amberstone Biosciences

Amolyt Pharma

Amylyx Pharmaceuticals

AnHeart Therapeutics

Anagram Therapeutics

Ancora Biotech LLC

Andes

Andson Biotech

Anebulo Pharmaceuticals

Angiex

Angiocrine Bioscience

Anima Biotech

Ankyra

Annexon Biosciences

Anodyne Nanotech

Anokion

Bolt Biotherapeutics is developing immuno-oncology therapies to eliminate tumors. Many tumors create an immune-suppressive environment to prevent their clearance. Bolt is leveraging the precision of antibody targeting to activate both the immune response in the tumor microenvironment. By identifying immune-stimulating antibody conjugates (ISACs), which Bolt refers to as Boltbody, a localized anti-tumor immune cascade can be stimulated to offer personalized therapeutic options. Using this approach, Bolt can address difficult-to-treat solid tumors and generate long-term anti-tumor responses through immunological memory. Bolt’s lead candidate, BDC-1001, is a HER2 BoltBody ISAC that is currently in clinical development for the treatment of patients with HER2-expressing solid tumors. 

<p>Bolt Biotherapeutics is developing immuno-oncology therapies to eliminate tumors. Many tumors create an immune-suppressive environment to prevent their clearance. Bolt is leveraging the precision of antibody targeting to activate both the immune response in the tumor microenvironment. By identifying immune-stimulating antibody conjugates (ISACs), which Bolt refers to as Boltbody, a localized anti-tumor immune cascade can be stimulated to offer personalized therapeutic options. Using this approach, Bolt can address difficult-to-treat solid tumors and generate long-term anti-tumor responses through immunological memory. Bolt’s lead candidate, BDC-1001, is a HER2 BoltBody ISAC that is currently in clinical development for the treatment of patients with HER2-expressing solid tumors. </p>


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