Scientist/Senior Scientist – Oligonucleotide Therapeutics | Neurodegeneration | Early-Stage Biotech

About the Job

·      Title: Scientist/Senior Scientist – Oligonucleotide Therapeutics | Neurodegeneration | Early-Stage Biotech

·      Type: Full-time, On site

·      Location: Boston MA

NuCyRNA Therapeutics

NuCyRNA Therapeutics, invested by Eli Lilly, Mission BioCapital, and Ono Pharma, was founded by a team of distinguished scientists with expertise in oligonucleotide technology, neuroscience, and NewCo creation.

The company's mission is to transform RNA-targeting therapeutics through its innovative oligonucleotide technology. The technology has demonstrated unique RNA-targeting capacities and a remarkable therapeutic index profile, particularly in the central nervous system (CNS).

NuCyRNA focuses on developing disease-modifying therapeutics to neurodegenerative diseases, which have significant unmet medical needs in our rapid aging society.

What you will do in this position

You will contribute to, and in some cases lead, the preclinical development of oligonucleotide therapeutics for neurodegenerative diseases.

1.    Wet lab experiments

a.    Conducting cell culture and molecular biology experiments (RT-qPCR, western blot).

b.    RNA and protein analysis of mouse brain samples, with the option to gain additional hands-on experience in animal studies if desired.

2.    CRO management: collaborate with and oversee CRO partners conducting in vitro and in vivo studies. Ensure scientific rigor through data quality control (e.g., RT-qPCR) and contribute to study design and interpretation.

3.    Working with the co-founder team on various tasks.

Background and qualifications

1.    Scientific Background – Candidates should have expertise in at least one of the following areas:

a.    RNA biology (e.g., RNA silencing, RNA splicing)

b.    Neurodegenerative diseases (e.g., ALS, Huntington’s disease)

c.    Oligonucleotide drug development

2.    Education – PhD or MD required. Recent PhD graduates and postdoctoral researchers are encouraged to apply. Candidates with significant relevant experience but without a PhD/MD will also be considered.

3.    Required Skills:

a.    Hands-on experience with mammalian cell culture

b.    RNA analysis using RT-qPCR and/or RNA sequencing

4.    Preferred (but not required): Industry experience in oligonucleotide therapeutics and/or neurodegenerative disease research.

Compensation package

We offer a competitive compensation package, including salary, equity, and benefits tailored to early-stage biotech scientists.

Career Advancement Opportunities

As the second FTE, you'll work directly with NuCyRNA Therapeutics' founders, advisors, and CROs. This position offers exposure to multiple startup aspects, including scientific research, business operations, strategic planning, and intellectual property management. The role provides opportunities for rapid professional growth and financial rewards as the company expands.

What we value at NuCyRNA

1.    Entrepreneurial Spirit: We seek individuals who embody an entrepreneurial mindset, demonstrating initiative, creativity, and adaptability in approaching challenges and opportunities.

2.    Execution Excellence: We place a strong emphasis on the ability to execute experiment plans efficiently and effectively.

3.    Scientific Integrity: We uphold high standards of scientific communication, valuing transparency and accuracy in all our research. Our team members are expected to maintain open and honest dialogue regarding scientific matters.

4.    Professional Growth: At NuCyRNA, we value the professional development of our team members. We believe in nurturing talent and providing pathways for advancement within NuCyRNA.

NuCyRNA offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a competitive package. Being part of the NuCyRNA team allows you to become part of a small team that supports professional development while working together to address the huge unmet medical need in neurodegenerative diseases such ALS & Huntington’s Disease.

How to apply

Application link based on Google Forms: https://forms.gle/GSXYVxc71rpwLB816

Applications are reviewed on a rolling basis, so we encourage you to submit your application as early as possible. We aim to make decisions by Jun 12. If the Google Forms link is active, we are still accepting applications.

For any questions, please email info@nucyrnatx.com. Please note that the CV/resume should only be uploaded via the Google Forms link above, not sent to this email.